Courteney Cox, Melissa Barrera and Jenna Ortega return to star in this sixth instalment of the slasher horror franchise. Following the events of 'Scream' (2022), Sam (Barrera) and Tara (Ortega) have moved to New York City along with fellow survivors Mindy (Jasmin Savoy Brown) and Chad (Mason Gooding). They were hoping for a fresh start, but as Sam continues to struggle with her father's murderous legacy, a new killer dons the Ghostface mask and leaves a trail of bodies in their wake.